It has previously been shown that there is a tremendous variation in the health gains made by subjects who follow a fully compliant and supervised exercise-training program. In fact for two of the most powerful biomarkers for future risk of cardiovascular and death, insulin action and aerobic fitness, some subjects actually demonstrate no measurable response to training.

A core aim of this FP7 project is to identify molecular biomarkers for response to exercise training, so that individualised lifestyle strategies can be developed to fight or prevent metabolic diseases such as obesity, diabetes and cardiovascular disease.

A major novelty of our programme, is that we use the new time-efficient exercise tool called ‘HIT’. HIT (High Intensity Training) can improve your aerobic fitness and insulin action with as little as 6 minutes of exercise per week. What we aim to prove is for whom it works best for and how it impacts on body composition and other important health parameters.

We will use state-of-the-art informatic techniques through our SME partners XRGenomics LTD and MPI, to develop genuinely translational discoveries by producing molecular ‘predictors’ for the personalised clinical response to exercise training. We will also produce greater insight into how the human body responds to exercise training to that potential alternative solutions can be found for those subjects that do not respond well to standard government guidelines for physical activity.

In sedentary over-weight subjects, a reduced fasting insulin level is a sign of improved insulin function (meaning better clearance of glucose from the blood stream), which in turn can reduce the risk of developing Type 2 Diabetes.

One of the key aims of Metapredict, therefore, is to identify genes that explain why some people do not respond well to aerobic exercise training.